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Kumar, Pravin
- Natural and Synthetic Polymers for Colon Targeted Drug Delivery
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Authors
Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P)-177101, IN
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Kangra (H.P)-177101, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 1 (2016), Pagination: 35-44Abstract
Colon targeted drug delivery system have recently gained importance in delivery of number of therapeutic agents for both local and systemic action. Colon targeted drug delivery system is useful for delivery of proteins and peptides, drugs undergoing degradation in stomach and small intestine. Targeting of drugs to colon is also favorable for the chronotherapy of diseases. To achieve successful, colonic delivery, a drug is needed to be protected from absorption in upper gastrointestinal tract (GIT). Out of the several approaches for colon targeting, coating the drug core with a polymer or polymer combinations is an important strategy. Coating of drug core with a pH dependent polymer or a polymer biodegraded in colon by colonic flora has been widely investigated approach for colonic delivery. Polysaccharides are important polymers from either natural or synthetic origin which have been exhaustively studied for successful colon targeting. This review describes some important natural and synthetic polysaccharides and polymers investigated for colonic drug delivery by coating the drug core.Keywords
Colon, Polymer, Coating, Biodegradation, Polysaccharide.
- Gold Nanoparticle-Small Drug Molecule Conjugates:Therapeutic Applications and Benefits as Compared to Free Drug
Abstract Views :431 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kangra, H. P., IN
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kangra, H. P., IN
Source
Asian Journal of Pharmacy and Technology, Vol 8, No 1 (2018), Pagination: 52-62Abstract
Gold nanoparticles (AuNPs) have been profoundly investigated for drug delivery applications. Various widely used small drugs molecules when conjugated either covalently or non-covalently with the AuNPs, showed improved therapeutic effect with reduced dose and adverse effects as compared to drug alone. This review focuses on therapeutic efficiency of AuNPs-small drug molecule conjugates as anti-cancer, anti-bacterial, antiretroviral and anti-arthritic agents. The basic approaches of conjugation, brief of procedure followed for activity determination and mechanism of action of conjugates have also been discussed.Keywords
Gold, Nanoparticles, Drug Conjugates, Anti-Cancer, Anti-Bacterial, Drug Delivery.References
- Farady M. Experimental relations of gold (and other metals) to light. Phil Trans R Soc London. 1875; 14: 145-81.
- Kumar D, Saini N, Jain N, Sareen R, Pandit V. Gold nanoparticles: an era in bionanotechnology. Expert Opin Drug Delivery.
- Hirsch LR, Stafford RJ, Bankson JA, et al. Nanoshell - mediated near infra-red thermal therapy of tumors under magnetic resonance guide. ProcNatlAcadSci USA. 2003; 100: 13549-54.
- Christopher LB, Bushell G, et al. Nanogold pharmaceutics. Gold bulletin. 2007; 40: 245.
- Leonaviciene L, Kirdaite R, et al. Effect of gold nanoparticles in the treatment of established collagen arthritis in rats. Medicinia (Kaunas). 2012; 48: 91.
- Li X, Robinson SM, Gupta A, Saha K, Jiang Z, Moyano DF et al. Functional gold nanoparticles as potent antimicrobial agents against multi drug resistant bacteria. ACS Nano. DOI: 10.1021/nn5042625
- Venkatachalam M, Govindaraju K, Mohamed Sadiq A, Tamilselvan S, Ganesh Kumar V, Singaravelu G. Functionalization of gold nanoparticles as anti-diabetic nanomaterial. Spectrochim Acta A Mol Biomol Spectrosc. 2013; 116: 331-38.
- Daisy P, Saipriya K. Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. Int J Nanomedicine. 2012; 7: 1189-1202.
- Vigderman L, Zubarev ER. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules. Adv Drug Del Rev. 2013; 65: 663-676.
- Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applicatons. Adv Drug Del Rev. 2008; 60: 1307-15.
- Bhumkar DR, Joshi HM, Sastry M, Pokharkar VB. Chitosan reduced gold nanoparticles as novel carrier for transmucosal delivery of insulin. Pharm Res. 2007; 24: 1415-26.
- Oshi M, Nakaogami J, Ishii T, Nagasaki Y. Smart PEGylated gold nanoparticles for the cytoplasmic delivery of s-RNA to induce enhanced gene silencing. ChemLett. 2006; 35: 1046-47.
- Wang H, Chen Y, Li XY, Liu Y. Synthesis of oligo(ethylenediamino)-β-cyclodextrn modified gold nanoparticle as a DNA concentrator. Mol Pharm. 2007; 4: 189-98.
- Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles.ProcNatlAcad Sci. 2008; 105: 17356-61.
- Dhar S, Liu Z, Thomale JE, Dai H, Lippard SJ. Targeted singlewall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J Am Chem Soc. 2008; 130: 11467-76.
- Feazell RP, Nakayama-Ratchford N, Dai H, Lippard SJ. Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. J Am Chem Soc. 2007; 129: 8438–39.
- Dhar S, Daniel WL, Giljohann DA, Mirkin CA, Lippard SJ. Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum (IV) warheads. J Am Chem Soc. 2009; 131: 14652-53.
- Min Y, Mao C, Xu D, Wang J, Liu Y. Gold nanorods for platinum based prodrug delivery. Chem Commun. 2010; 46: 8424-26.
- Patra CR, Bhattacharya R, Mukherjee P. Fabricatin and functional characterization of gold nanoconjugates for potential application in ovarian cancer. J Mater Chem. 2010; 20 (3): 547-53.
- Brown SD, Nativo P, Smith JA, Stirling D, Edwards PR, Venugopal B, Flint DJ, Plumb JA, Graham D, Wheate NJ. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J Am Chem Soc. 2010; 132 (13): 4678-84. doi: 10.1021/ja908117a.
- C Senthil Kumar MD, Raja D, SatihishSundar M, Grover Antoniraj K Rukmani. Hyaluronic aacid co-functionalized gold nanoparticle for targeted delivery of metformin in the treatment of liver cancer (HepG2 cells). Carbohydrate polymer. http://dx.doi.org/doi:10.1016/j.carbpol.2015.04.010
- Joshi P, Chakaraborty S, Dey S, Shanker V, Ansari ZA, Singh SP, Chakrabarti P. Binding of chloroquine conjugated gold nanoparticles with bovine serum albumin. Journal of colloid and interface science. 2011; 355: 402-9.
- KhaingOo MK, Yang X, Du H, Wang H. 5-amino levulinic acid conjugated gold nanoparticles for photodynamic therapy of cancer. Nanomedicine. 2008; 2: 12-15.
- Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH et al. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in syngeneic lung tumor model. Mol Pharmaceutics. 2007; 4 (5): 713-22.
- Murawala P, Tirmale A, Shiras A, Prasad BLV. In situ synthesized BSA capped gold nanoparticles: Effective carrier of anticancer drug Methotrexate to MCF-7 breast cancer cells. Materials Science and Engineering. 2014; 34: 158-67.
- Podsiadlo P, Sinani VA, Bahng JH, Kam NWS, Lee J, Kotov NA. Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurinechemotherapeutic agent. Langmuir. 2008; 24: 568-74.
- Gibson JD, Khanal BP, Zubarev ER. Paclitaxel-functionalized gold nanoparticles. J Am Chem Soc. 2007; 129 (37): 11653-61.
- Hwu JR, Lin YS, Josephrajan T, Hsu MH, Cheng FY, Yeh CS, Su DC, Shieh DB. Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles. J Am Chem Soc. 2008; 131: 66-68.
- Zhang XQ, Xu X, Lam R, Giljohann D, Ho D, Mirkin CA. Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA nanoparticle conjugates. ACS Nano. 2011; 5 (9): 6962-70.
- Heo DN, Yang DH, Moon HJ, Lee JB, Bae MS, Lee SC, Lee WJ, Sun IC, Kwon KI. Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy. Biomaterial. 2012; 33: 856-66.
- Wang F, Wang FC, Dou S, Xiong MH, Sun TM, Wang J. Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano. 2011; 5: 3679-92.
- Bae Y, Fukushima S, Harada A, Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew ChemInt Ed. 2003; 42: 4640-43.
- Kim B, Han G, Toley B, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010; 5 (6): 465-72.
- Shirazi AN, Mandal D, Tiwari RK, Guao L, Lu W, Parang K. Cyclic peptide capped gold nanoparticles as drug delivery systems. Mol Pharmaceutics. 2013; 10 (2): 500-511.
- Agasti SS, Chompoosor A, You CC, Ghosh P, Kim CK, Rotello VM. Photoregulated release of caged anticancer drugs from gold nanoparticles. J Am Chem Soc. 2009; 131 (16): 5728-29.
- Dreaden EC, Mwakwari SC, Sodji QH, Oyelere AK, El-Sayed MA. Tamoxifen poly(ethylene glycol) thiol gold nanoparticle conjugates: enhanced potency andselective delivery for breast cancer treatment. Bioconjugate Chem. 2009; 20 (12): 2247-53.
- Hosta L, Pla-Roca M, Arbiol J, Lo¦üpez-Iglesias C, Samitier J, Cruz LZ, Kogan MJ, Albericio F, Conjugation of kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity. Bioconjugate Chem. 2008: 20: 138-46.
- Kim CK, Ghosh P, Pagliuca C, Zhu ZJ, Menichetti S, Rotello VM. Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells. J Am Chem Soc. 2009; 131 (4): 1360-61.
- Cheng Y, Samia AC, Meyers JD, Panagopoulos I, Fei B, Burda C. Highly efficient drug delivery with gold nanoparticle vectors for in vivophotodynamic therapy of cancer. J Am Chem Soc. 2008; 130 (32): 10643-47.
- Dixit SK, Zhu Y, Moore A, Kenney M, Broome AM. Doubletargeted theranostic gold nanoparticles for treatment of brain tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5413. doi:10.1158/1538-7445.AM2014-5413.
- Tomuleasa C, Soritau O, Orza A, Dudea M, Petrushev B, Mosteanu O, Susman S, Florea A, Pall E, Aldea M, Kacso G, Cristea V, Berindan-Neagoe I, Irimie A. Gold nanoparticles conjugated with cisplatin/doxorubicin/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells. J Gastro Intestin Liver Dis. 2012; 21 (2): 187-96.
- Grace AN, Pandian K. Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles brief study. Colloids Surf. 2007; A 297: 63–70.
- Grace AN, Pandian K. Quinolone antibiotic-capped gold nanoparticles and their antibacterial efficacy against gram positive and gram negative organisms. J Bionanosci. 2007; 1: 96-105.
- Saha B, Bhattacharya J, Mukherjee A, Ghosh A, Santra C, Dasgupta A, Karmakar P. in vitro structural and functional evaluation of gold nanoparticles conjugated antibiotics.Nanoscale Res Lett.2007; 2: 614-22.
- Burygin GL, Khlebtsov BN, Shantrokha AN, Dykman LA, Bogatyrev VA, Khlebtsov NG. On the enhanced antibacterial activity of antibiotics mixed with goldnanoparticles. Nanoscale Res Lett. 2009; 4: 794-801.
- Rastogi L. Kora AJ, Arunachalam J. Highly stable, protein capped gold nanoparticles as effective drug delivery vehicles for amino glycosides antibiotics. Materials Science and Engineering C. 2012; 32: 1571-77.
- Rai A, Prabhune A, Perry CC. Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings. J Mater Chem. 2010; 20: 6789-98.
- Tom RJ, Suryanarayanan V, Reddy PG, Baskaran S, Pradeep T. Ciprofloxacin protected gold nanoparticles. Langmuir. 2004; 20: 1909-14.
- Loechler, E.L., King, J., 1986. Identification of the 9-aminoacridine/DNA complex responsible for photodynamic inactivation of P22. Biochemistry. 25, 5858–5864.
- Zhu, H., Clark, S.M., Benson, S.C., Rye, A.N., Mathies, A.N., 1994. High-sensitivity capillary electrophoresis of double-stranded DNA fragments using monomeric and dimeric fluorescent intercalating. Dyes Anal. Chem. 66, 1941–1948.
- Mitra P, Chakraborty PK, Saha P, Ray P, Basu S. Antibacterial efficacy of acridine derivatives conjugated with gold nanoparticles. Int J Pharm. 2014; 473: 636-43.
- Gu H, Ho PL, Tong E, Wang L, Xu B. Presenting vancomycin on nanoparticles to enhance antimicrobial activities. Nano Letters. 2003; 3 (9): 1261-63.
- Huang WC, Tsai PJ, Chen YC. Functional gold nanoparticles as photothermal agents for selective-killing of pathogenic bacteria. Nanomedicine. 2007; 2 (6): 777-87.
- Tomas JG, Tubby S, Parkin IP, Narband N, Dekker L, Nair SP, Wilson M, Street C. Lethal photosensitisation of Staphylococcus aureus using a toluidine blueO-tiopronin–gold nanoparticle conjugate. J Mater Chem. 2007; 17: 3739-46.
- Zhao Y, Tian Y, Cui Y, Liu W, Ma W, Jiang X. Small molecule-capped gold nanoparticles as potent antibacterial agents that target gram-negative bacteria. J Am Chem Soc. 2010; 132 (35): 1234956.
- Zhao Y, Chen Z, Chen Y, Xu J, Li J, Jiang X. Synergy of nonantibiotic drugs and pyrimidinethiol on gold nanoparticles against superbugs. J Am Chem Soc. 2013; 135 (35): 12940-43.
- Bowman MC, Ballard TE, Ackerson CJ, Feldheim DL, Margolis DM, Melander C. Inhibition of HIV fusion with multivalent gold nanoparticles. J Am Chem Soc. 2008;130(22):6896-97.
- Gomes A, Datta P, Sengupta J, Biswas A, Gomes A. Evaluation of anti-arthritic property of methotrexate conjugated gold nanoparticle on experimental animal models. J Nanopharmaceutics Drug Delivery. 2013; 1 (1): 1-6.